| Product name | Evodiamine |
| Other name | EVODIAMINE10% PLANTEXTRACT;EVODIAMINE98%; EVODIAMINE20%PLANTEXTRACT; EVODIAMINE5%PLANTEXTRACT; Evodiaminestd ; EVODIAMINE; 8,13,13b,14-Tetrahydro-14-mChemicalbookethylindolo[2'3'-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one; Indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(S)- |
| CAS No. | 518-17-2 |
| Molecular formula | C19H17N3O |
| Molecular weight | 303.36 |
| Purity | 98.0% |
| Appearance | Light yellow crystalline powder |
| Packing | 1kg/ pack |
| Application | Pharmaceutical raw material |
Evodiamine is a quinolone alkaloid isolated from Evodia rutaecarpa. 1 Evodia Rutaecarpa is a very popular herb used in traditional Chinese medicine to treat a variety of ailments. Evodiamine has been shown to elicit a variety of biological effects including induction of apoptosis, inhibiting cancer cell proliferation, promoting cell cycle arrest in G2/M, inhibiting invasion and metastasis of cancer cells, inhibiting angiogenesis, induction of oxidative stress and subsequent apoptosis and inhibition of NF-κB.2 It also functions as an agonist of TRPV1 (EC50 = 1.03 μM) 3 and acts as an anti-inflammatory agent4.Evodiamine is a kind of natural indole alkaloid, and is also the main biological active component of Chinese medicine Fructus officinalis. Anti-tumor, stomach strengthening, stop retching and belching, heart protection, weight loss, anti-inflammatory, analgesic and other pharmacological activities, the treatment of AD and stroke has a certain effect. As a natural new anticancer drug, Cornus officinalis can inhibit the proliferation of a variety of tumor cells, including cervical cancer, colon cancer, Escherichia coli, lung cancer, melanoma, T lymphocytic leukemia, prostate cancer, breast cancer and other tumor cell proliferation has a strong inhibitory effect. It also has other biological activities, such as regulating body temperature, anti-hypoxia, dermatological applications, bronchoconstriction and hormone secretion regulation, etc. In addition, fructus officinalis has good binding ability to a variety of proteins, so it can be used as a multi-target compound to play a variety of biological activities.
1. Anti-inflammatory effect: Evodiamine has certain anti-inflammatory effect and has certain application value in the treatment of infectious diseases. 2. Role of reproductive system: Evodiamine can inhibit the synthesis of male hormones, which is helpful for the treatment of prostate cancer and other diseases. 3. Biotransformation: Evodiamine can be converted by bacteria in the gut into other compounds, which can play different roles.
